36 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2007-11-17 | H | Hartford | 6 | W | 104 | 69 | 1-0 | 0-0 | 19,147 | Louisville | KY | Freedom Hall | 2007 Las Vegas Invitational | |
| 2007-11-18 | H | Jackson State | 6 | W | 84 | 53 | 2-0 | 0-0 | 19,121 | Louisville | KY | Freedom Hall | 2007 Las Vegas Invitational | |
| 2007-11-21 | A | Nevada-Las Vegas | 6 | W | 68 | 48 | 3-0 | 0-0 | 14,133 | Las Vegas | NV | Thomas & Mack Center | ||
| 2007-11-23 | N | Brigham Young | 6 | L | 76 | 78 | 3-1 | 0-0 | 4,590 | Las Vegas | NV | Orleans Arena | 2007 Las Vegas Invitational | |
| 2007-11-24 | N | Old Dominion | 6 | W | 64 | 53 | 4-1 | 0-0 | 5,500 | Las Vegas | NV | Orleans Arena | 2007 Las Vegas Invitational | |
| 2007-12-01 | H | Miami, Ohio | 12 | W | 47 | 44 | 5-1 | 0-0 | 19,427 | Louisville | KY | Freedom Hall | ||
| 2007-12-08 | H | Dayton | 14 | L | 65 | 70 | 5-2 | 0-0 | 19,128 | Louisville | KY | Freedom Hall | ||
| 2007-12-15 | N | Purdue | 22 | L | 59 | 67 | 5-3 | 0-0 | 17,170 | Indianapolis | IN | Conseco Fieldhouse | 2007 John Wooden Tradition | |
| 2007-12-18 | H | Marshall | W | 85 | 75 | 6-3 | 0-0 | 19,036 | Louisville | KY | Freedom Hall | |||
| 2007-12-22 | H | New Mexico State | W | 70 | 65 | 7-3 | 0-0 | 19,021 | Louisville | KY | Freedom Hall | 2007 Billy Minardi Classic | ||
| 2007-12-26 | H | Morehead State | W | 73 | 49 | 8-3 | 0-0 | 19,366 | Louisville | KY | Freedom Hall | |||
| 2007-12-29 | H | Iona | W | 67 | 36 | 9-3 | 0-0 | 19,118 | Louisville | KY | Freedom Hall | |||
| 2008-01-01 | H | Cincinnati | L | 57 | 58 | 9-4 | 0-1 | 19,488 | Louisville | KY | Freedom Hall | |||
| 2008-01-05 | A | Kentucky | W | 89 | 75 | 10-4 | 0-1 | 24,386 | Lexington | KY | Rupp Arena | |||
| 2008-01-10 | H | West Virginia | W | 63 | 54 | 11-4 | 1-1 | 19,764 | Louisville | KY | Freedom Hall | |||
| 2008-01-13 | A | Rutgers | W | 64 | 49 | 12-4 | 2-1 | 5,879 | Piscataway | NJ | Louis Brown Athletic Center | |||
| 2008-01-17 | H | 13 | Marquette | W | 71 | 51 | 13-4 | 3-1 | 19,834 | Louisville | KY | Freedom Hall | ||
| 2008-01-19 | A | Seton Hall | L | 82 | 92 | 13-5 | 3-2 | 9,800 | Newark | NJ | Prudential Center | |||
| 2008-01-23 | A | South Florida | W | 80 | 60 | 14-5 | 4-2 | 4,781 | Tampa | FL | USF Sun Dome | |||
| 2008-01-26 | H | St. John's | W | 67 | 57 | 15-5 | 5-2 | 19,462 | Louisville | KY | Freedom Hall | |||
| 2008-01-28 | A | Connecticut | L | 67 | 69 | 15-6 | 5-3 | 15,120 | Hartford | CT | XL Center | |||
| 2008-02-02 | H | Rutgers | W | 87 | 50 | 16-6 | 6-3 | 19,397 | Louisville | KY | Freedom Hall | |||
| 2008-02-04 | A | 16 | Marquette | W | 71 | 57 | 17-6 | 7-3 | 17,736 | Milwaukee | WI | Bradley Center | ||
| 2008-02-09 | H | 6 | Georgetown | W | 59 | 51 | 18-6 | 8-3 | 20,083 | Louisville | KY | Freedom Hall | ||
| 2008-02-12 | A | DePaul | 23 | W | 88 | 68 | 19-6 | 9-3 | 9,828 | Rosemont | IL | Allstate Arena | ||
| 2008-02-16 | A | Providence | 23 | W | 80 | 72 | 20-6 | 10-3 | 12,500 | Providence | RI | Dunkin' Donuts Center | ||
| 2008-02-18 | H | Syracuse | 18 | W | 61 | 50 | 21-6 | 11-3 | 19,868 | Louisville | KY | Freedom Hall | ||
| 2008-02-24 | A | Pittsburgh | 18 | W | 75 | 73 | 22-6 | 12-3 | 12,508 | Pittsburgh | PA | Petersen Events Center | ||
| 2008-02-28 | H | 17 | Notre Dame | 13 | W | 90 | 85 | 23-6 | 13-3 | 19,881 | Louisville | KY | Freedom Hall | |
| 2008-03-02 | H | Villanova | 13 | W | 68 | 54 | 24-6 | 14-3 | 20,043 | Louisville | KY | Freedom Hall | ||
| 2008-03-08 | A | 11 | Georgetown | 12 | L | 52 | 55 | 24-7 | 14-4 | 19,116 | Washington | DC | Verizon Center | |
| 2008-03-13 | N | Pittsburgh | 13 | L | 69 | 76 | 24-8 | 14-4 | 19,562 | New York | NY | Madison Square Garden IV | 2008 Big East Tournament Quarterfinal | |
| 2008-03-21 | N | Boise State | 13 | W | 79 | 61 | 25-8 | 14-4 | 14,315 | Birmingham | AL | BJCC Arena | 2008 NCAA Tournament East Regional First Round | |
| 2008-03-23 | N | Oklahoma | 13 | W | 78 | 48 | 26-8 | 14-4 | 14,606 | Birmingham | AL | BJCC Arena | 2008 NCAA Tournament East Regional Second Round | |
| 2008-03-27 | N | 5 | Tennessee | 13 | W | 79 | 60 | 27-8 | 14-4 | 19,092 | Charlotte | NC | Charlotte Bobcats Arena | 2008 NCAA Tournament East Regional Semifinal |
| 2008-03-29 | N | 1 | North Carolina | 13 | L | 73 | 83 | 27-9 | 14-4 | 19,092 | Charlotte | NC | Charlotte Bobcats Arena | 2008 NCAA Tournament East Regional Final |