35 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2010-11-16 | H | 16 | Butler | W | 88 | 73 | 1-0 | 0-0 | 22,723 | Louisville | KY | KFC Yum! Center | ||
| 2010-11-20 | H | Jackson State | W | 62 | 45 | 2-0 | 0-0 | 22,289 | Louisville | KY | KFC Yum! Center | 2010 Global Sports Shootout | ||
| 2010-11-22 | H | Chattanooga | W | 106 | 65 | 3-0 | 0-0 | 21,191 | Louisville | KY | KFC Yum! Center | 2010 Global Sports Shootout | ||
| 2010-11-27 | H | Marshall | W | 80 | 66 | 4-0 | 0-0 | 21,262 | Louisville | KY | KFC Yum! Center | 2010 Global Sports Shootout | ||
| 2010-12-01 | H | Florida International | W | 92 | 55 | 5-0 | 0-0 | 20,866 | Louisville | KY | KFC Yum! Center | 2010 Global Sports Shootout | ||
| 2010-12-04 | H | South Alabama | W | 97 | 70 | 6-0 | 0-0 | 21,048 | Louisville | KY | KFC Yum! Center | |||
| 2010-12-08 | H | San Francisco | 24 | W | 61 | 35 | 7-0 | 0-0 | 21,049 | Louisville | KY | KFC Yum! Center | ||
| 2010-12-11 | H | 20 | Nevada-Las Vegas | 24 | W | 77 | 69 | 8-0 | 0-0 | 22,489 | Louisville | KY | KFC Yum! Center | 2010 Billy Minardi Classic |
| 2010-12-14 | H | Drexel | 20 | L | 46 | 52 | 8-1 | 0-0 | 20,912 | Louisville | KY | KFC Yum! Center | ||
| 2010-12-18 | H | Gardner-Webb | 20 | W | 78 | 49 | 9-1 | 0-0 | 20,434 | Louisville | KY | KFC Yum! Center | ||
| 2010-12-22 | A | Western Kentucky | W | 114 | 82 | 10-1 | 0-0 | 7,326 | Bowling Green | KY | Diddle Arena | |||
| 2010-12-27 | H | Morgan State | 22 | W | 104 | 74 | 11-1 | 0-0 | 21,688 | Louisville | KY | KFC Yum! Center | ||
| 2010-12-31 | H | 11 | Kentucky | 22 | L | 63 | 78 | 11-2 | 0-0 | 22,803 | Louisville | KY | KFC Yum! Center | |
| 2011-01-05 | H | Seton Hall | W | 73 | 54 | 12-2 | 1-0 | 21,912 | Louisville | KY | KFC Yum! Center | |||
| 2011-01-09 | A | South Florida | W | 86 | 77 | 13-2 | 2-0 | 4,375 | Tampa | FL | USF Sun Dome | |||
| 2011-01-12 | A | 7 | Villanova | 18 | L | 74 | 88 | 13-3 | 2-1 | 13,199 | Philadelphia | PA | Wells Fargo Center | |
| 2011-01-15 | H | Marquette | 18 | W | 71 | 70 | 14-3 | 3-1 | 21,485 | Louisville | KY | KFC Yum! Center | ||
| 2011-01-19 | H | St. John's | 19 | W | 88 | 63 | 15-3 | 4-1 | 21,638 | Louisville | KY | KFC Yum! Center | ||
| 2011-01-22 | A | Providence | 19 | L | 67 | 72 | 15-4 | 4-2 | 12,051 | Providence | RI | Dunkin' Donuts Center | ||
| 2011-01-26 | H | West Virginia | 23 | W | 55 | 54 | 16-4 | 5-2 | 21,957 | Louisville | KY | KFC Yum! Center | ||
| 2011-01-29 | A | 5 | Connecticut | 23 | W | 79 | 78 | 17-4 | 6-2 | 10,167 | Storrs | CT | Harry A. Gampel Pavilion | |
| 2011-01-31 | A | 13 | Georgetown | 15 | L | 59 | 62 | 17-5 | 6-3 | 12,164 | Washington | DC | Verizon Center | |
| 2011-02-05 | H | DePaul | 15 | W | 61 | 57 | 18-5 | 7-3 | 21,704 | Louisville | KY | KFC Yum! Center | ||
| 2011-02-09 | A | 8 | Notre Dame | 16 | L | 79 | 89 | 18-6 | 7-4 | 8,659 | South Bend | IN | Purcell Pavillion at Joyce Center | |
| 2011-02-12 | H | 12 | Syracuse | 16 | W | 73 | 69 | 19-6 | 8-4 | 22,755 | Louisville | KY | KFC Yum! Center | |
| 2011-02-16 | A | Cincinnati | 16 | L | 54 | 63 | 19-7 | 8-5 | 11,511 | Cincinnati | OH | Fifth Third Arena | ||
| 2011-02-18 | H | 13 | Connecticut | 16 | W | 71 | 58 | 20-7 | 9-5 | 22,776 | Louisville | KY | KFC Yum! Center | |
| 2011-02-22 | A | Rutgers | 16 | W | 55 | 37 | 21-7 | 10-5 | 5,633 | Piscataway | NJ | Louis Brown Athletic Center | ||
| 2011-02-27 | H | 4 | Pittsburgh | 16 | W | 62 | 59 | 22-7 | 11-5 | 22,758 | Louisville | KY | KFC Yum! Center | |
| 2011-03-02 | H | Providence | 11 | W | 87 | 60 | 23-7 | 12-5 | 22,724 | Louisville | KY | KFC Yum! Center | ||
| 2011-03-05 | A | West Virginia | 11 | L | 70 | 72 | 23-8 | 12-6 | 15,032 | Morgantown | WV | WVU Coliseum | ||
| 2011-03-10 | N | Marquette | 14 | W | 81 | 56 | 24-8 | 12-6 | 19,375 | New York | NY | Madison Square Garden IV | 2011 Big East Tournament Quarterfinal | |
| 2011-03-11 | N | 4 | Notre Dame | 14 | W | 83 | 77 | 25-8 | 12-6 | 19,375 | New York | NY | Madison Square Garden IV | 2011 Big East Tournament Semifinal |
| 2011-03-12 | N | 21 | Connecticut | 14 | L | 66 | 69 | 25-9 | 12-6 | 19,375 | New York | NY | Madison Square Garden IV | 2011 Big East Tournament Final |
| 2011-03-17 | N | Morehead State | 14 | L | 61 | 62 | 25-10 | 12-6 | 18,499 | Denver | CO | Pepsi Center | 2011 NCAA Tournament Southwest Regional Second Round |