37 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2008-11-22 | H | Morehead State | 3 | W | 79 | 41 | 1-0 | 0-0 | 19,493 | Louisville | KY | Freedom Hall | 2008 Billy Minardi Classic | |
| 2008-11-23 | H | South Alabama | 3 | W | 81 | 54 | 2-0 | 0-0 | 19,241 | Louisville | KY | Freedom Hall | 2008 Billy Minardi Classic | |
| 2008-11-30 | N | Western Kentucky | 3 | L | 54 | 68 | 2-1 | 0-0 | 8,193 | Nashville | TN | Sommet Center | ||
| 2008-12-06 | H | Indiana State | 11 | W | 83 | 43 | 3-1 | 0-0 | 18,924 | Louisville | KY | Freedom Hall | 2008 Marques Maybin Classic | |
| 2008-12-07 | H | Ohio | 11 | W | 91 | 56 | 4-1 | 0-0 | 19,083 | Louisville | KY | Freedom Hall | 2008 Marques Maybin Classic | |
| 2008-12-08 | H | Lamar | 9 | W | 78 | 56 | 5-1 | 0-0 | 19,058 | Louisville | KY | Freedom Hall | 2008 Marques Maybin Classic | |
| 2008-12-13 | H | Austin Peay | 9 | W | 94 | 75 | 6-1 | 0-0 | 19,288 | Louisville | KY | Freedom Hall | ||
| 2008-12-18 | N | Mississippi | 9 | W | 77 | 68 | 7-1 | 0-0 | 5,922 | Cincinnati | OH | U.S. Bank Arena | 2008 SEC Big East Challenge | |
| 2008-12-20 | N | Minnesota | 9 | L | 64 | 70 | 7-2 | 0-0 | 10,431 | Glendale | AZ | University of Phoenix Stadium | 2008 Stadium Shootout | |
| 2008-12-27 | H | Alabama-Birmingham | 19 | W | 82 | 62 | 8-2 | 0-0 | 19,627 | Louisville | KY | Freedom Hall | ||
| 2008-12-31 | H | Nevada-Las Vegas | 18 | L | 55 | 56 | 8-3 | 0-0 | 19,314 | Louisville | KY | Freedom Hall | ||
| 2009-01-04 | H | Kentucky | 18 | W | 74 | 71 | 9-3 | 0-0 | 20,078 | Louisville | KY | Freedom Hall | ||
| 2009-01-07 | A | South Florida | 23 | W | 71 | 57 | 10-3 | 1-0 | 4,827 | Tampa | FL | USF Sun Dome | ||
| 2009-01-10 | A | 18 | Villanova | 23 | W | 61 | 60 | 11-3 | 2-0 | 17,117 | Philadelphia | PA | Wachovia Center | |
| 2009-01-12 | H | 12 | Notre Dame | 20 | W | 87 | 73 | 12-3 | 3-0 | 19,865 | Louisville | KY | Freedom Hall | |
| 2009-01-17 | H | 1 | Pittsburgh | 20 | W | 69 | 63 | 13-3 | 4-0 | 20,082 | Louisville | KY | Freedom Hall | |
| 2009-01-21 | A | Rutgers | 9 | W | 78 | 59 | 14-3 | 5-0 | 5,178 | Piscataway | NJ | Louis Brown Athletic Center | ||
| 2009-01-25 | A | 8 | Syracuse | 9 | W | 67 | 57 | 15-3 | 6-0 | 25,721 | Syracuse | NY | Carrier Dome | |
| 2009-01-28 | H | South Florida | 7 | W | 80 | 54 | 16-3 | 7-0 | 17,184 | Louisville | KY | Freedom Hall | ||
| 2009-01-31 | H | West Virginia | 7 | W | 69 | 63 | 17-3 | 8-0 | 19,416 | Louisville | KY | Freedom Hall | ||
| 2009-02-02 | H | 1 | Connecticut | 5 | L | 51 | 68 | 17-4 | 8-1 | 20,069 | Louisville | KY | Freedom Hall | |
| 2009-02-08 | A | St. John's | 5 | W | 60 | 47 | 18-4 | 9-1 | 6,128 | New York | NY | Madison Square Garden IV | ||
| 2009-02-12 | A | Notre Dame | 5 | L | 57 | 90 | 18-5 | 9-2 | 11,418 | South Bend | IN | Joyce Athletic and Convocation Center | ||
| 2009-02-15 | H | DePaul | 5 | W | 99 | 54 | 19-5 | 10-2 | 19,322 | Louisville | KY | Freedom Hall | ||
| 2009-02-18 | H | Providence | 7 | W | 94 | 76 | 20-5 | 11-2 | 19,484 | Louisville | KY | Freedom Hall | ||
| 2009-02-21 | A | Cincinnati | 7 | W | 72 | 63 | 21-5 | 12-2 | 12,350 | Cincinnati | OH | Fifth Third Arena | ||
| 2009-02-23 | A | Georgetown | 6 | W | 76 | 58 | 22-5 | 13-2 | 12,653 | Washington | DC | Verizon Center | ||
| 2009-03-01 | H | 8 | Marquette | 6 | W | 62 | 58 | 23-5 | 14-2 | 20,079 | Louisville | KY | Freedom Hall | |
| 2009-03-04 | H | Seton Hall | 6 | W | 95 | 78 | 24-5 | 15-2 | 19,535 | Louisville | KY | Freedom Hall | ||
| 2009-03-07 | A | West Virginia | 6 | W | 62 | 59 | 25-5 | 16-2 | 13,089 | Morgantown | WV | WVU Coliseum | ||
| 2009-03-12 | N | Providence | 5 | W | 73 | 55 | 26-5 | 16-2 | 19,375 | New York | NY | Madison Square Garden IV | 2009 Big East Tournament Quarterfinal | |
| 2009-03-13 | N | 10 | Villanova | 5 | W | 69 | 55 | 27-5 | 16-2 | 19,375 | New York | NY | Madison Square Garden IV | 2009 Big East Tournament Semifinal |
| 2009-03-14 | N | 18 | Syracuse | 5 | W | 76 | 66 | 28-5 | 16-2 | 19,375 | New York | NY | Madison Square Garden IV | 2009 Big East Tournament Final |
| 2009-03-20 | N | Morehead State | 1 | W | 74 | 54 | 29-5 | 16-2 | 12,499 | Dayton | OH | University of Dayton Arena | 2009 NCAA Tournament Midwest Regional First Round | |
| 2009-03-22 | N | Siena | 1 | W | 79 | 72 | 30-5 | 16-2 | 12,596 | Dayton | OH | University of Dayton Arena | 2009 NCAA Tournament Midwest Regional Second Round | |
| 2009-03-27 | N | Arizona | 1 | W | 103 | 64 | 31-5 | 16-2 | 33,780 | Indianapolis | IN | Lucas Oil Stadium | 2009 NCAA Tournament Midwest Regional Semifinal | |
| 2009-03-29 | N | 8 | Michigan State | 1 | L | 52 | 64 | 31-6 | 16-2 | 36,084 | Indianapolis | IN | Lucas Oil Stadium | 2009 NCAA Tournament Midwest Regional Final |