33 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2009-11-17 | N | Arkansas | 20 | W | 96 | 66 | 1-0 | 0-0 | 12,017 | St. Louis | MO | Scottrade Center | 2009 Hall of Fame Showcase | |
| 2009-11-21 | H | East Tennessee State | 20 | W | 69 | 56 | 2-0 | 0-0 | 19,179 | Louisville | KY | Freedom Hall | 2009 Hall of Fame Showcase | |
| 2009-11-22 | H | Morgan State | 20 | W | 90 | 81 | 3-0 | 0-0 | 18,942 | Louisville | KY | Freedom Hall | 2009 Hall of Fame Showcase | |
| 2009-11-23 | H | Appalachian State | 16 | W | 80 | 53 | 4-0 | 0-0 | 19,027 | Louisville | KY | Freedom Hall | 2009 Hall of Fame Showcase | |
| 2009-11-28 | A | Nevada-Las Vegas | 16 | L | 71 | 76 | 4-1 | 0-0 | 14,390 | Las Vegas | NV | Thomas & Mack Center | ||
| 2009-12-02 | H | Stetson | 20 | W | 80 | 48 | 5-1 | 0-0 | 18,916 | Louisville | KY | Freedom Hall | ||
| 2009-12-05 | H | Charlotte | 20 | L | 65 | 87 | 5-2 | 0-0 | 19,221 | Louisville | KY | Freedom Hall | ||
| 2009-12-12 | H | Western Carolina | L | 83 | 91 | 5-3 | 0-0 | 19,247 | Louisville | KY | Freedom Hall | |||
| 2009-12-16 | H | Oral Roberts | W | 94 | 57 | 6-3 | 0-0 | 18,868 | Louisville | KY | Freedom Hall | |||
| 2009-12-19 | H | Western Kentucky | W | 102 | 75 | 7-3 | 0-0 | 19,531 | Louisville | KY | Freedom Hall | 2009 Billy Minardi Classic | ||
| 2009-12-23 | H | Louisiana-Lafayette | W | 84 | 69 | 8-3 | 0-0 | 18,894 | Louisville | KY | Freedom Hall | |||
| 2009-12-27 | H | Radford | W | 79 | 53 | 9-3 | 0-0 | 19,265 | Louisville | KY | Freedom Hall | |||
| 2009-12-30 | H | South Florida | W | 73 | 52 | 10-3 | 1-0 | 19,386 | Louisville | KY | Freedom Hall | |||
| 2010-01-02 | A | 3 | Kentucky | L | 62 | 71 | 10-4 | 1-0 | 24,479 | Lexington | KY | Rupp Arena | ||
| 2010-01-06 | A | Providence | W | 92 | 70 | 11-4 | 2-0 | 9,207 | Providence | RI | Dunkin' Donuts Center | |||
| 2010-01-09 | H | St. John's | W | 75 | 68 | 12-4 | 3-0 | 19,263 | Louisville | KY | Freedom Hall | |||
| 2010-01-11 | H | 4 | Villanova | L | 84 | 92 | 12-5 | 3-1 | 20,076 | Louisville | KY | Freedom Hall | ||
| 2010-01-16 | A | 16 | Pittsburgh | L | 77 | 82 | 12-6 | 3-2 | 12,781 | Pittsburgh | PA | Petersen Events Center | ||
| 2010-01-21 | A | Seton Hall | L | 77 | 80 | 12-7 | 3-3 | 7,139 | Newark | NJ | Prudential Center | |||
| 2010-01-24 | H | Cincinnati | W | 68 | 60 | 13-7 | 4-3 | 19,617 | Louisville | KY | Freedom Hall | |||
| 2010-01-30 | A | 9 | West Virginia | L | 74 | 77 | 13-8 | 4-4 | 12,471 | Morgantown | WV | WVU Coliseum | ||
| 2010-02-01 | H | Connecticut | W | 82 | 69 | 14-8 | 5-4 | 19,655 | Louisville | KY | Freedom Hall | |||
| 2010-02-06 | H | Rutgers | W | 76 | 60 | 15-8 | 6-4 | 19,775 | Louisville | KY | Freedom Hall | |||
| 2010-02-11 | A | St. John's | L | 55 | 74 | 15-9 | 6-5 | 5,748 | New York | NY | Madison Square Garden IV | |||
| 2010-02-14 | A | 2 | Syracuse | W | 66 | 60 | 16-9 | 7-5 | 31,053 | Syracuse | NY | Carrier Dome | ||
| 2010-02-17 | H | Notre Dame | W | 91 | 89 | 17-9 | 8-5 | 19,623 | Louisville | KY | Freedom Hall | |||
| 2010-02-20 | A | DePaul | W | 68 | 59 | 18-9 | 9-5 | 13,754 | Rosemont | IL | Allstate Arena | |||
| 2010-02-23 | H | 11 | Georgetown | L | 60 | 70 | 18-10 | 9-6 | 19,917 | Louisville | KY | Freedom Hall | ||
| 2010-02-28 | A | Connecticut | W | 78 | 76 | 19-10 | 10-6 | 10,167 | Storrs | CT | Harry A. Gampel Pavilion | |||
| 2010-03-02 | A | Marquette | L | 48 | 69 | 19-11 | 10-7 | 16,281 | Milwaukee | WI | Bradley Center | |||
| 2010-03-06 | H | 1 | Syracuse | W | 78 | 68 | 20-11 | 11-7 | 20,135 | Louisville | KY | Freedom Hall | ||
| 2010-03-10 | N | Cincinnati | L | 66 | 69 | 20-12 | 11-7 | 19,375 | New York | NY | Madison Square Garden IV | 2010 Big East Tournament Second Round | ||
| 2010-03-19 | N | California | L | 62 | 77 | 20-13 | 11-7 | 12,251 | Jacksonville | FL | Jacksonville Veterans Memoria Arena | 2010 NCAA Tournament South Regional First Round |