34 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2005-11-19 | H | Tennessee-Martin | 7 | W | 78 | 61 | 1-0 | 0-0 | 18,138 | Louisville | KY | Freedom Hall | ||
| 2005-12-03 | H | Prairie View A&M | 7 | W | 90 | 65 | 2-0 | 0-0 | 18,628 | Louisville | KY | Freedom Hall | 2005 Colonial Classic | |
| 2005-12-04 | H | Arkansas State | 7 | W | 67 | 55 | 3-0 | 0-0 | 18,742 | Louisville | KY | Freedom Hall | 2005 Colonial Classic | |
| 2005-12-05 | H | Richmond | 5 | W | 53 | 45 | 4-0 | 0-0 | 18,491 | Louisville | KY | Freedom Hall | 2005 Colonial Classic | |
| 2005-12-10 | H | Akron | 5 | W | 111 | 85 | 5-0 | 0-0 | 18,841 | Louisville | KY | Freedom Hall | ||
| 2005-12-13 | H | Chicago State | 4 | W | 78 | 54 | 6-0 | 0-0 | 18,794 | Louisville | KY | Freedom Hall | ||
| 2005-12-17 | A | 23 | Kentucky | 4 | L | 61 | 73 | 6-1 | 0-0 | 24,432 | Lexington | KY | Rupp Arena | |
| 2005-12-20 | H | Middle Tennessee | 11 | W | 76 | 68 | 7-1 | 0-0 | 18,884 | Louisville | KY | Freedom Hall | 2005 Billy Minardi Classic | |
| 2005-12-21 | H | College of Charleston | 11 | W | 78 | 63 | 8-1 | 0-0 | 18,927 | Louisville | KY | Freedom Hall | 2005 Billy Minardi Classic | |
| 2005-12-24 | H | Detroit Mercy | 11 | W | 56 | 48 | 9-1 | 0-0 | 17,824 | Louisville | KY | Freedom Hall | ||
| 2005-12-28 | H | Fairleigh Dickinson | 10 | W | 89 | 66 | 10-1 | 0-0 | 18,833 | Louisville | KY | Freedom Hall | ||
| 2005-12-31 | N | Miami, Fla. | 10 | W | 58 | 43 | 11-1 | 0-0 | 10,916 | Sunrise | FL | BankAtlantic Center | 2005 MetroPCS Orange Bowl Classic | |
| 2006-01-05 | H | 3 | Villanova | 9 | L | 67 | 76 | 11-2 | 0-1 | 20,058 | Louisville | KY | Freedom Hall | |
| 2006-01-07 | A | Providence | 9 | W | 72 | 67 | 12-2 | 1-1 | 9,554 | Providence | RI | Dunkin' Donuts Center | ||
| 2006-01-09 | H | UC Davis | 10 | W | 81 | 58 | 13-2 | 1-1 | 18,816 | Louisville | KY | Freedom Hall | ||
| 2006-01-15 | H | 12 | Pittsburgh | 10 | L | 57 | 61 | 13-3 | 1-2 | 19,947 | Louisville | KY | Freedom Hall | |
| 2006-01-17 | A | St. John's | 17 | L | 56 | 68 | 13-4 | 1-3 | 5,224 | New York | NY | Madison Square Garden IV | ||
| 2006-01-21 | H | 3 | Connecticut | 17 | L | 58 | 71 | 13-5 | 1-4 | 20,091 | Louisville | KY | Freedom Hall | |
| 2006-01-25 | H | Cincinnati | 22 | W | 67 | 50 | 14-5 | 2-4 | 19,684 | Louisville | KY | Freedom Hall | ||
| 2006-01-28 | A | Rutgers | 22 | L | 56 | 65 | 14-6 | 2-5 | 8,097 | Piscataway | NJ | Louis Brown Athletic Center | ||
| 2006-01-30 | A | 4 | Villanova | L | 73 | 79 | 14-7 | 2-6 | 19,448 | Philadelphia | PA | Wachovia Center | ||
| 2006-02-04 | H | Notre Dame | W | 89 | 86 | 15-7 | 3-6 | 19,327 | Louisville | KY | Freedom Hall | |||
| 2006-02-06 | A | Cincinnati | L | 68 | 74 | 15-8 | 3-7 | 13,176 | Cincinnati | OH | Fifth Third Arena | |||
| 2006-02-11 | H | South Florida | W | 57 | 54 | 16-8 | 4-7 | 19,308 | Louisville | KY | Freedom Hall | |||
| 2006-02-18 | A | Syracuse | L | 66 | 79 | 16-9 | 4-8 | 31,190 | Syracuse | NY | Carrier Dome | |||
| 2006-02-22 | H | DePaul | W | 65 | 53 | 17-9 | 5-8 | 18,991 | Louisville | KY | Freedom Hall | |||
| 2006-02-25 | A | 14 | West Virginia | L | 64 | 68 | 17-10 | 5-9 | 12,483 | Morgantown | WV | WVU Coliseum | ||
| 2006-03-01 | H | Marquette | W | 67 | 60 | 18-10 | 6-9 | 19,505 | Louisville | KY | Freedom Hall | |||
| 2006-03-04 | A | 2 | Connecticut | L | 80 | 84 | 18-11 | 6-10 | 10,167 | Storrs | CT | Harry A. Gampel Pavilion | ||
| 2006-03-08 | N | 8 | Pittsburgh | L | 56 | 61 | 18-12 | 6-10 | 19,594 | New York | NY | Madison Square Garden IV | 2006 Big East Tournament First Round | |
| 2006-03-17 | H | Delaware State | W | 71 | 54 | 19-12 | 6-10 | 14,132 | Louisville | KY | Freedom Hall | 2006 NIT First Round | ||
| 2006-03-20 | H | Clemson | W | 74 | 68 | 20-12 | 6-10 | 12,344 | Louisville | KY | Freedom Hall | 2006 NIT Second Round | ||
| 2006-03-22 | H | Missouri State | W | 74 | 56 | 21-12 | 6-10 | 14,658 | Louisville | KY | Freedom Hall | 2006 NIT Quarterfinal | ||
| 2006-03-28 | N | South Carolina | L | 63 | 78 | 21-13 | 6-10 | 7,473 | New York | NY | Madison Square Garden IV | 2006 NIT Semifinal |