34 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2006-11-18 | H | Northwestern State | W | 100 | 87 | 1-0 | 0-0 | 17,234 | Louisville | KY | Freedom Hall | |||
| 2006-11-24 | N | Dayton | L | 64 | 68 | 1-1 | 0-0 | 8,250 | Cincinnati | OH | U.S. Bank Arena | |||
| 2006-12-02 | H | Sacramento State | W | 99 | 69 | 2-1 | 0-0 | 17,219 | Louisville | KY | Freedom Hall | |||
| 2006-12-05 | N | 14 | Arizona | L | 65 | 72 | 2-2 | 0-0 | 10,611 | New York | NY | Madison Square Garden IV | 2006 Jimmy V Classic | |
| 2006-12-08 | H | Ohio | W | 74 | 71 | 3-2 | 0-0 | 17,791 | Louisville | KY | Freedom Hall | 2006 NABC Classic | ||
| 2006-12-09 | H | Saint Joseph's, Pa. | W | 74 | 64 | 4-2 | 0-0 | 17,811 | Louisville | KY | Freedom Hall | 2006 NABC Classic | ||
| 2006-12-10 | H | Bellarmine | W | 76 | 64 | 5-2 | 0-0 | 16,788 | Louisville | KY | Freedom Hall | 2006 NABC Classic | ||
| 2006-12-13 | H | Massachusetts | L | 68 | 72 | 5-3 | 0-0 | 18,464 | Louisville | KY | Freedom Hall | 2006 Billy Minardi Classic | ||
| 2006-12-16 | H | Kentucky | L | 49 | 61 | 5-4 | 0-0 | 20,042 | Louisville | KY | Freedom Hall | |||
| 2006-12-20 | H | Savannah State | W | 71 | 45 | 6-4 | 0-0 | 16,694 | Louisville | KY | Freedom Hall | |||
| 2006-12-23 | H | Miami, Fla. | W | 82 | 59 | 7-4 | 0-0 | 18,234 | Louisville | KY | Freedom Hall | |||
| 2006-12-27 | H | Northeastern | W | 61 | 41 | 8-4 | 0-0 | 17,843 | Louisville | KY | Freedom Hall | |||
| 2006-12-28 | H | San Francisco | W | 76 | 63 | 9-4 | 0-0 | 17,622 | Louisville | KY | Freedom Hall | |||
| 2006-12-30 | H | UNC Asheville | W | 66 | 51 | 10-4 | 0-0 | 17,408 | Louisville | KY | Freedom Hall | |||
| 2007-01-03 | A | 17 | Notre Dame | L | 62 | 78 | 10-5 | 0-1 | 8,580 | South Bend | IN | Joyce Athletic and Convocation Center | ||
| 2007-01-10 | A | South Florida | W | 81 | 55 | 11-5 | 1-1 | 4,410 | Tampa | FL | USF Sun Dome | |||
| 2007-01-13 | H | Providence | W | 78 | 63 | 12-5 | 2-1 | 18,731 | Louisville | KY | Freedom Hall | |||
| 2007-01-15 | H | 24 | Marquette | L | 65 | 74 | 12-6 | 2-2 | 19,434 | Louisville | KY | Freedom Hall | ||
| 2007-01-20 | A | DePaul | W | 59 | 50 | 13-6 | 3-2 | 13,022 | Rosemont | IL | Allstate Arena | |||
| 2007-01-22 | H | Connecticut | W | 68 | 54 | 14-6 | 4-2 | 19,876 | Louisville | KY | Freedom Hall | |||
| 2007-01-27 | H | Syracuse | W | 76 | 71 | 15-6 | 5-2 | 19,894 | Louisville | KY | Freedom Hall | |||
| 2007-01-31 | A | Cincinnati | W | 69 | 53 | 16-6 | 6-2 | 10,881 | Cincinnati | OH | Fifth Third Arena | |||
| 2007-02-03 | A | Villanova | L | 53 | 57 | 16-7 | 6-3 | 17,133 | Philadelphia | PA | Wachovia Center | |||
| 2007-02-07 | H | 22 | Georgetown | L | 65 | 73 | 16-8 | 6-4 | 20,030 | Louisville | KY | Freedom Hall | ||
| 2007-02-10 | H | South Florida | W | 83 | 63 | 17-8 | 7-4 | 19,302 | Louisville | KY | Freedom Hall | |||
| 2007-02-12 | A | 7 | Pittsburgh | W | 66 | 53 | 18-8 | 8-4 | 12,065 | Pittsburgh | PA | Petersen Events Center | ||
| 2007-02-17 | A | 12 | Marquette | W | 61 | 59 | 19-8 | 9-4 | 18,904 | Milwaukee | WI | Bradley Center | ||
| 2007-02-21 | H | St. John's | 20 | W | 72 | 48 | 20-8 | 10-4 | 19,634 | Louisville | KY | Freedom Hall | ||
| 2007-02-25 | A | Connecticut | 20 | W | 76 | 69 | 21-8 | 11-4 | 16,294 | Hartford | CT | Hartford Civic Center | ||
| 2007-03-04 | H | Seton Hall | 16 | W | 86 | 71 | 22-8 | 12-4 | 19,712 | Louisville | KY | Freedom Hall | ||
| 2007-03-08 | N | West Virginia | 12 | W | 82 | 71 | 23-8 | 12-4 | 19,594 | New York | NY | Madison Square Garden IV | 2007 Big East Tournament Quarterfinal | |
| 2007-03-09 | N | 13 | Pittsburgh | 12 | L | 59 | 65 | 23-9 | 12-4 | 19,594 | New York | NY | Madison Square Garden IV | 2007 Big East Tournament Semifinal |
| 2007-03-15 | N | Stanford | 16 | W | 78 | 58 | 24-9 | 12-4 | 20,816 | Lexington | KY | Rupp Arena | 2007 NCAA Tournament South Regional First Round | |
| 2007-03-17 | N | 9 | Texas A&M | 16 | L | 69 | 72 | 24-10 | 12-4 | 20,882 | Lexington | KY | Rupp Arena | 2007 NCAA Tournament South Regional Second Round |