31 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2015-11-13 | H | Samford | W | 86 | 45 | 1-0 | 0-0 | 20,347 | Louisville | KY | KFC Yum! Center | |||
| 2015-11-17 | H | Hartford | W | 87 | 52 | 2-0 | 0-0 | 18,910 | Louisville | KY | KFC Yum! Center | 2015 Brooklyn Hoops Holiday Invitational | ||
| 2015-11-21 | H | North Florida | W | 89 | 61 | 3-0 | 0-0 | 20,413 | Louisville | KY | KFC Yum! Center | 2015 Brooklyn Hoops Holiday Invitational | ||
| 2015-11-24 | H | St. Francis Brooklyn | W | 85 | 41 | 4-0 | 0-0 | 19,112 | Louisville | KY | KFC Yum! Center | 2015 Brooklyn Hoops Holiday Invitational | ||
| 2015-11-28 | N | Saint Louis | W | 77 | 57 | 5-0 | 0-0 | 4,273 | Brooklyn | NY | Barclays Center | 2015 Brooklyn Hoops Holiday Invitational | ||
| 2015-12-02 | A | 3 | Michigan State | 24 | L | 67 | 71 | 5-1 | 0-0 | 14,797 | East Lansing | MI | Breslin Center | 2015 Big Ten-ACC Challenge |
| 2015-12-05 | H | Grand Canyon | 24 | W | 111 | 63 | 6-1 | 0-0 | 20,380 | Louisville | KY | KFC Yum! Center | ||
| 2015-12-12 | H | Eastern Michigan | 22 | W | 86 | 53 | 7-1 | 0-0 | 20,649 | Louisville | KY | KFC Yum! Center | ||
| 2015-12-16 | H | Kennesaw State | 19 | W | 94 | 57 | 8-1 | 0-0 | 19,288 | Louisville | KY | KFC Yum! Center | ||
| 2015-12-19 | H | Western Kentucky | 19 | W | 78 | 56 | 9-1 | 0-0 | 21,606 | Louisville | KY | KFC Yum! Center | ||
| 2015-12-22 | H | Missouri-Kansas City | 16 | W | 75 | 47 | 10-1 | 0-0 | 19,419 | Louisville | KY | KFC Yum! Center | 2015 Billy Minardi Classic | |
| 2015-12-23 | H | Utah Valley | 16 | W | 98 | 68 | 11-1 | 0-0 | 19,146 | Louisville | KY | KFC Yum! Center | 2015 Billy Minardi Classic | |
| 2015-12-26 | A | 12 | Kentucky | 16 | L | 73 | 75 | 11-2 | 0-0 | 24,412 | Lexington | KY | Rupp Arena | |
| 2016-01-03 | H | Wake Forest | 18 | W | 65 | 57 | 12-2 | 1-0 | 21,302 | Louisville | KY | KFC Yum! Center | ||
| 2016-01-07 | A | North Carolina State | 16 | W | 77 | 72 | 13-2 | 2-0 | 17,762 | Raleigh | NC | PNC Arena | ||
| 2016-01-10 | A | Clemson | 16 | L | 62 | 66 | 13-3 | 2-1 | 9,562 | Greenville | SC | Bon Secours Wellness Arena | ||
| 2016-01-14 | H | 20 | Pittsburgh | 21 | W | 59 | 41 | 14-3 | 3-1 | 21,632 | Louisville | KY | KFC Yum! Center | |
| 2016-01-20 | H | Florida State | 17 | W | 84 | 65 | 15-3 | 4-1 | 21,349 | Louisville | KY | KFC Yum! Center | ||
| 2016-01-23 | A | Georgia Tech | 17 | W | 75 | 71 | 16-3 | 5-1 | 7,829 | Atlanta | GA | McCamish Pavilion | ||
| 2016-01-27 | A | Virginia Tech | 16 | W | 91 | 83 | 17-3 | 6-1 | 7,084 | Blacksburg | VA | Cassell Coliseum | ||
| 2016-01-30 | H | 11 | Virginia | 16 | L | 47 | 63 | 17-4 | 6-2 | 21,714 | Louisville | KY | KFC Yum! Center | |
| 2016-02-01 | H | 2 | North Carolina | 19 | W | 71 | 65 | 18-4 | 7-2 | 22,781 | Louisville | KY | KFC Yum! Center | |
| 2016-02-06 | H | Boston College | 19 | W | 79 | 47 | 19-4 | 8-2 | 21,803 | Louisville | KY | KFC Yum! Center | ||
| 2016-02-08 | A | Duke | 13 | L | 65 | 72 | 19-5 | 8-3 | 9,314 | Durham | NC | Cameron Indoor Stadium | ||
| 2016-02-13 | A | Notre Dame | 13 | L | 66 | 71 | 19-6 | 8-4 | 9,149 | South Bend | IN | Joyce Athletic and Convocation Center | ||
| 2016-02-17 | H | Syracuse | 18 | W | 72 | 58 | 20-6 | 9-4 | 21,654 | Louisville | KY | KFC Yum! Center | ||
| 2016-02-20 | H | 20 | Duke | 18 | W | 71 | 64 | 21-6 | 10-4 | 22,785 | Louisville | KY | KFC Yum! Center | |
| 2016-02-24 | A | Pittsburgh | 11 | W | 67 | 60 | 22-6 | 11-4 | 10,425 | Pittsburgh | PA | Petersen Events Center | ||
| 2016-02-27 | A | 12 | Miami, Fla. | 11 | L | 65 | 73 | 22-7 | 11-5 | 7,342 | Coral Gables | FL | BankUnited Center | |
| 2016-03-01 | H | Georgia Tech | 11 | W | 56 | 53 | 23-7 | 12-5 | 22,043 | Louisville | KY | KFC Yum! Center | ||
| 2016-03-05 | A | 4 | Virginia | 11 | L | 46 | 68 | 23-8 | 12-6 | 14,088 | Charlottesville | VA | John Paul Jones Arena |